What is Diclazepam ?
Diclazepam is also known in the medical circles as Chlorodiazepam. The drug is analog of diazepam, being included in the larger family of the benzodiazepine class of medication. Diclazepam was first synthesized in the year 1960 at Hoffman-La Roche by Leo Sternbach and his team. The drug’s effects are similar to those of diazepam but with a potency of only around 10 times that of diazepam. Diclazepam is having amnestic, depressant, muscle relaxant, sedative, hypnotic, anticonvulsant and anxiolytic properties in animal models.
Currently, the drug is sold as a research chemical and not yet marketed as a medication because it has not been tested systematically in humans. Diclazepam’s closest relatives and two main metabolites are delorazepam and lormetazepam. Delorazepam has around 10 times the potency value of diazepam and lormetazepam has a potency of around 10 to 12 times of delorazepam.
It is known in the medical community that the sudden discontinuation of benzodiazepines can be life-threatening or at least pose dangers for individuals who used them regularly over a long period of time. Among the negative effects of sudden withdrawal are included the risk of seizures or even death. For this reason, in order to stop taking the drug after using it for long, it is highly recommended to gradually lower the amount taken each day over a certain period of time instead of abruptly stopping.
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Chemistry of Diclazepam
As already mentioned above, diclazepam is a drug included in the benzodiazepine class. Benzodiazepine substances contain a benzene ring that is fused to a diazepine ring. The diazepine ring is a seven-membered ring that contains two nitrogen constituents located at R1 and R4. Diclazepam is substituted with a methyl group at R1. A 2-chlorinated phenyl ring is bonded to the benzodiazepine ring at R5. A chlorine group R7 is replacing the benzyl ring. In order to form a ketone, diclazepam also contains an oxygen group double bonded to R2 of its diazepine ring. Other benzodiazepine drugs with the suffix -azepam also share this oxygen substitution at R2.
Due to their chemical formula, Benzodiazepines produce a variety of effects. These effects are mostly generated by acting on the receptors of the neurotransmitter gamma-aminobutyric acid (GABA) and magnifying their efficiency and effects, as well as binding to the benzodiazepine receptor site. On the receptors of the neurotransmitter gamma-aminobutyric acid (GABA), diclazepam is considered to be best receptor inhibitor within the brain. Among the results of its modulation are included the calming or sedating effects. By binding its receptors to voltage-dependent sodium channels rather than benzodiazepine, the drug has also anticonvulsant properties.
The drug has several subjective effects and generates various personal experiences. However, these effects will rarely occur in the same time. It is more likely to experience all the effects in case of heavier doses use. The same goes for adverse effects. On higher doses, the risk of experiencing these effects increases and may even include death or severe injury.
- Physical effects
Using this substance could alter the energy level. It can lead to an overwhelmingly lethargic state, being extremely sedating. Users could suddenly feel at higher levels as if they lack days of sleep, being in an extreme state sleep deprivation. If this is the case then engaging in physical activities becomes difficult. The drug is making users prone to faint or at least feel as if they are on the verge of passing out and need to sit down. The feeling of sleep deprivation can eventually make a person to faint. The risk is increasing proportionally to dosage. Other possible physical effects include dizziness, muscle relaxation, respiratory depression and motor control loss.
- Cognitive effects
The cognitive effects progressively intensify proportional to dosage. The general cognitive effect of the drug is described by many as one of decreased inhibition and intense sedation. Among the typical depressant, cognitive effects are generally included compulsive redosing, information processing suppression, disinhibition, analysis suppression, thought deceleration, anxiety suppression, and amnesia.
An emotion suppression effect could also be experienced. This compound primarily suppresses anxiety but can also dull other emotions even if in a manner that is less intensive than the antipsychotic drugs. Despite obvious evidence to the contrary such as an inability to fully communicate with others and severe cognitive impairment, the drug can also generate some delusions of sobriety, giving a false belief that one is perfectly sober. This effect occurs most commonly at heavy dosages.
- Paradoxical effects
Among the paradoxical reactions to benzodiazepines are included loss of impulse control, violent behavior, aggression, increased seizures (in epileptics), irritability and suicidal behavior. However, with an incidence rate below 1%, these reactions are rare in the general population. A greater frequency of occurrence for these paradoxical effects has been reported in children, individuals with mental disorders, recreational abusers, and patients on high-dosage regimes.
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Harm potential and toxicity levels of Diclazepam
Diclazepam’s toxicity depends on dosage but it’s generally low. However, when taking it together with depressants like opioids and alcohol, the drug can potentially become lethal. For this reason, users of diclazepam should follow some harm reduction practices.
Addiction potential and tolerance
Diclazepam can be extremely psychologically and physically addictive.
Within a couple of days of continuous use, consumers of the drug will develop tolerance to the sedative-hypnotic effects. The tolerance returns to baseline in around 7 to 14 days after cessation. However, proportional to the duration and intensity of one’s long-term usage, in certain cases, this may take significantly longer.
After ceasing usage abruptly following a few weeks or longer of steady dosing, rebound symptoms or withdrawal symptoms could occur. In this case, it may be necessary to implement a gradual dose reduction process. In general, tapering from benzodiazepines needs to occur in a controlled manner. Benzodiazepine discontinuation is a notoriously difficult process that can even become potentially life-threatening for those individuals using the drugs regularly and try to discontinue use too fast, without tapering their dose over a period of weeks. In this case, could increase the risk of seizures, hypertension and even death. During withdrawal should be avoided drugs such as tramadol.
Cross-tolerance with all benzodiazepines is present for diclazepam. After consuming the substance, all other benzodiazepine drugs will have just a reduced effect.
As it is also happening with many other drugs, consuming diclazepam can become risky and even life-threatening when it is taken together with other medicines. The lethal risk still increases even if it may be safe to take the combinations of drugs in low doses of each.
In combination with certain depressants like 2-methyl-2-butanol, 1,4-butanediol, barbiturates, alcohol, methaqualone, GHB/GBL and opioids, dangerous or even lethal levels of respiratory depression can occur. Because all these substances increase the effects of amnesia, sedation and muscle relaxation, at high doses they can pose the risk of unexpected loss of consciousness. During unconsciousness, it also increases the risk of vomiting and the resulting suffocation can be fatal. In order to avoid this risk, users should try to sleep in the recovery position.
In combination with dissociative drugs, it can also increase the risk of vomiting during unconsciousness. The resulting suffocation can lead to death. For this reason, users should try to fall asleep in the recovery position when consuming benzodiazepines in combination with dissociatives.
It is also dangerous to combine stimulants with benzodiazepines. This combination can lead to excessive intoxication. Most people tend to take into consideration when determining their level of intoxication the fact that stimulants lower the sedative effect of benzodiazepines. However, the effects of benzodiazepines will be significantly increased once the effect of the stimulant starts to wear off. This situation can lead to various secondary effects, including intensified disinhibition. Users should strictly limit themselves to just a certain amount of benzodiazepines per hour when combining them with stimulants. If users do not monitor hydration, it can also potentially lead to severe dehydration.
When a benzodiazepine is taken together with other depressants or in heavy quantities, overdose may occur. These drugs work in a similar fashion and for this reason, it becomes particularly dangerous to combine benzodiazepines with other GABAergic depressants such as alcohol and barbiturates. Their effects add together because the benzodiazepines and other depressants bind to allosteric sites on the GABAA receptor.
When both are consumed, the chlorine ion pore opens more frequently and stays open longer. Barbiturates increase the duration in which the chlorine ion pore opens on the GABAA receptor, while benzodiazepines increase the frequency in which they are open. If not treated promptly and properly, benzodiazepine overdose is a medical emergency that may lead to a permanent brain injury, coma or death.
Among the symptoms of a benzodiazepine overdose is included severe respiratory depression, slurred speech, thought deceleration, delusions, confusion, coma or death. Only in a hospital environment, benzodiazepine overdoses may be treated effectively, resulting generally favorable outcomes. The overdoses are sometimes treated with a GABAA antagonist that is called flumazenil.
The overdoses are sometimes treated with a GABAA antagonist that is called flumazenil.
Diclazepam is legal in the U.S., but is currently unscheduled in the U.K. In Germany, the drug was added on November 21, 2015, to the controlled substance act, which makes it illegal to produce, sell or possess.
Potential benefits of bodybuilding training
For bodybuilders willing to experiment in order to achieve the best results and performance, diclazepam has certain potential benefits. Assuming that one is experimenting with moderation and keep the dosage optimal to avoid eventual addiction and side effects, this novel compound can make a great alternative for those unable to work with Etizolam. Whatever quantity you use for your experiments, take care to use a reliable supplier that provides a great level of quality and purity.
It is incumbent on you, the ultimate user, to make your diligent research and be informed what exactly you are buying. It is recommended to avoid the mistake to overlook the necessity of investigating the reliability and reputation of the company who manufacturers the performance enhancing supplements.
You should always limit your purchases to those companies you trust, that receive positive reviews, and that you are familiar with. Only this way you can ensure achieving consistent results every time.
Being chemically similar in structure to chlorodiazepam, diclazepam is s a positive allosteric modulator of the benzodiazepine receptor. This property makes it able to act in as an anxiolytic and muscle relaxant, as proved by in vitro studies (outside living organism). These effects could be beneficial for your recovery phase, after your intensive training sessions.
As all athletes and bodybuilders know so well, some of the supplements they use for performance-enhancing can also cause side effects of insomnia, high blood pressure, anxiety, and tachycardia. Diclazepam could prove a great product that helps to avoid all these unpleasant symptoms. It can particularly be useful when trying to fall asleep after intense training sessions.
However, the main benefit of using the drug in your bodybuilding regimen is its quality to fight anxiety, whether it be general, social, or panic attacks. It can make you feel euphoric. You will have no worries and everything would feel like the best scenario. In proper dosage, this is excellent performance enhancing stuff for your training. Diclazepam could be safer and far superior to other benzos. It will be crushing your anxiety and boosting your mood, without really impair you. The drug could be also used for treating problems such as sleeplessness and panic disorder.
If you decide to experiment with this performance enhancer drug you should ensure to make your online purchases only from dependable and efficient vendors only. If you already have had a good experience with a certain vendor, it is recommended to adhere to only one supplier.
By purchasing from reliable online vendors, you ensure that the drug will be good quality and provide the most effective final results. When you’re preparing to buy online, do so from a genuine website that has been in this field for a long time. You may also want to ensure that the website has a real license and is certified.
You may find that numerous retailers or vendors of these research chemicals don’t provide delivery in certain countries. For this reason, it is important to find one that can deliver in your residing location.
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Sol Ruiz heads our Research Digest department. He graduated from the New York University where he obtained his Master’s Degree in Public Health.