Prednisone Review 2018- Benefits & Side Effects-

Introduction to Prednisone

Prednisone is a prescription steroid drug that comes as a delayed-release tablet, a liquid solution, and also as an immediate-release tablet. All these forms of the product are taken by mouth. Prednisone delayed-release tablet is available as the name of the brand which is known as Rayos and also as a generic drug. Prednisone immediate-release tablet is only available as a generic. Brand name versions cost way higher than generic drugs.

Prednisone is termed as a corticosteroid and helps in preventing the release of a substance that causes inflammation in the body. The immune system can also be suppressed by the medicine. Prednisone can also be used as an immunosuppressant medication and as an anti-inflammatory medication. Allergic disorders, ulcerative colitis, breathing disorders, skin conditions, lupus, arthritis, and psoriasis can also be treated by the medicine.

You need to note some few warnings before you start using the product and these are; it can weaken your immune system which leaves you vulnerable to infections. Therefore, you should avoid being near sick people especially anyone that has measles or chickenpox, as this can be very risky for you. Prednisone being a synthetic corticosteroid tends to mimic cortisol action, which is a corticosteroid that occurs naturally produced by the adrenal glands in the body.

Who Makes Prednisone?

Arthur Nobile in 1950 was the first person to isolate and structure identifications of Prednisolone and Prednisone. In 1955 the first commercially feasible synthesis of Prednisone was carried out in Schering Corporation laboratories. The Schering Corporation later became the Schering Plough Corporation by Arthur and coworkers.

Arthur Nobile and coworkers went on to discover that through the bacterium Corynebacterium simplex, cortisone could be oxidized to Prednisone microbiologically. Later on, through the experiments conducted on mice, enhanced activity of the corticoid of the compounds over hydrocortisone and cortisone was demonstrated. In 1955, Upjohn and Schering introduced Prednisolone and Prednisone under Delta-Cortef and Meticorten brand names.

You can be able to find these prescriptions as generic drugs from various manufacturers. The drug is actually very cheap and affordable and this makes it a convenient medication if it can help to treat the conditions stated. The tablets are used by the pharmaceutical industry for the dissolution testing equipment calibration. This is according to the USP (United States Pharmacopeia).

Benefits of Prednisone

The medicine comes with plenty of benefits in regards to the kind of help that it provides to the users. Therefore check out some of these benefits below.

The medicine helps to manage inflammatory diseases or conditions in which the important role is played by the immune system.

The medicine helps to treat many conditions and diseases but only some are approved, and these are; ulcerative colitis, allergic reactions, systemic lupus, various types of arthritis, severe psoriasis, Crohn’s disease, and asthma.

It can also help to treat; lymphomas, bronchitis, leukemia, autoimmune hemolytic anemia, and idiopathic thrombocytopenic purpura.

Patients whose adrenal glands are not able to produce sufficient amounts of cortisol can also use Prednisone as a therapy replacement.

Prednisone being a Corticosteroid helps to relieve inflammation, discomfort, and pain, among other conditions.

You need to inform your doctor before taking Prednisone if you have the following conditions;

  • If you have any history of malaria
  • If you have osteoporosis or tuberculosis
  • If you have diabetes or thyroid disorder
  • If you have a history of mental illness or depression
  • If you have herpes infection of the eyes or glaucoma
  • If you have high blood pressure or heart disease
  • If you have low levels of potassium in your blood
  • If you have kidney disease or any disease that causes diarrhea
  • If you have stomach ulcers or a history of stomach bleeding

Although Prednisone has its great advantages in treating most of the diseases mentioned above, you need to make sure that you inform your doctor in case you have the conditions outlined above. This is mainly because it can help your doctor administer the medication in the right way in order for it to be effective.

Side Effects of Prednisone

Just like every other product or medicine out there, it also features its drawbacks that you need to know about before starting to take the medicine.

Higher doses and more prolonged treatment of Prednisone and other corticosteroids can lead to frequent mild and serious damages, as well as irreversible organ damage.

The common side-effects of Prednisone include; gaining of weight, high blood pressure, acne, headache, vomiting, potassium loss, and muscle weakness, lack of sleep, skin thinning, restlessness, and nausea.

The most serious side effects resulting from taking Prednisone include; glaucoma, irregular menses, cataracts, obesity, stomach ulcers, convulsions, retardation of growth in children, heart attack, syncope, congestive heart failure, pulmonary adema, tachycardia, vasculitis, anemia, amnesia, pancreatitis, hypothyroidism, amenorrhea, low blood pressure, thrombophlebitis, hyperglycemia, and allergic dermatitis.

The psychiatric side-effects caused by Prednisone include; euphoria, mood swings, changes in one’s personality, psychotic behavior, depression, and insomnia.

Other side-effects that you also need to be aware of include; agitation, aggression, dizziness, irritability, ears pounding, breathing issues when at rest, swelling of the feet, fingers, lower legs, and hands.


Like all medication, it is administered according to your medical condition and response to the treatment.

First of all, you should know that the medicine should be taken with food.

Prednisone dosage starts from 5 to 60mg each day and can be adjusted according to how you respond to the treatment.

The medicine is a corticosteroid doesn’t produce effects immediately and takes days before all the effects start being seen.

If you stop taking Prednisone after taking it for so long, Prednisone dose must be lowered gradually to allow the recovery of adrenal glands.

Drugs are processed more slowly in older adults and therefore it is recommended to lower the dosage if you are a senior adult.

For children, the doctor is the one who should determine the dosage because they are usually based on weight.

It is available in generic form and you also need to note that you should always follow the doctor’s prescription to be on the safe side.

If you happen to overdose you should call emergency services immediately.

You also need to note that the medication should not be shared with anyone else even if the person has similar symptoms that you have.

Always store the medicine in a cool and dry place away from sunlight and moisture to keep safe.


Thomas Matthys a former world-class track & field athlete and the founder of Swol Headquarters. He graduated from the University of Fordham with a Master’s degree in Science. Matthys is a certified sports nutritionist and personal coach of several professional athletes.  Matthys has been involved in various clinical studies within Track & Field including one on the factors associated with muscle recovery and HIIT.

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