Premarin Review 2018- Benefits & Side Effects-

What is Premarin?

Premarin also was known as conjugated estrogen is a tablet that features a mixture of estrogen hormones which help in the treatment of menopause symptoms such as vaginal changes, hot flashes, and also in the prevention of osteoporosis. Estrogen is a female sex hormone which is produced by the ovaries and is quite necessary for various body processes.

Premarin is basically used by women to reduce menopause symptoms which are caused by the body making less estrogen. If you use Premarin for treating symptoms that are around the vagina, you need to consider the products that are applied inside the vagina directly before taking any other form of the medication such as absorbing through the skin medications taken by mouth.

There are also other various products that can be taken by women to prevent bone loss after menopause. You should also note that before you decide to use the product you can consider taking other medications such as bisphosphonates or raloxifene which also help in preventing bone, they are safer, and also quite effective. Men and women can also use certain products to treat various types of cancers such as breast cancer and prostate cancer, which may have spread to other parts of the body.

Who Makes Premarin?

The predecessor of Premarin was Emmenin, which was an extract of pregnant women’s urine. A very similar competing product was Progynon. Conjugated estrogen which is similar to Premarin was contained in both of these products. However, they were human estrogen and not equine estrogens, therefore, making a difference in the composition. Estriol glucuronide was the major active ingredient in Progynon and Emmenin.

In the late 30s, researchers in the Biochemistry department at the University of Toronto isolated Estrone sulfate from the urine of pregnant mares. In 1941 the first introduction of Premarin was done by Wyeth Ayerst for treatment of various menopause symptoms and hot flushes. The only thing that had to be proven at that time was the efficacy and safety of Premarin.

Premarin is manufactured by Pfizer, which is one of the world’s premier biopharmaceutical companies today. The medicine is also sold as a generic version from various manufacturers and comes at an affordable price. The treatment performed by Premarin is also very much beneficial to the users.

Check out some of the benefits below.

Benefits of Premarin

  • It features great benefits which are very convenient for the users due to the effective and working of the medication.
  • It provides relief for symptoms that are related to the vagina. These may include; painful intercourse and skin irritation.
  • Defective internal secretion of ovaries and metastatic breast carcinoma can be treated by Premarin.
  • It also helps to treat signs of “change of life” and primary ovarian failure.
  • Softening of the bones before menopause and wasting of tissues of the vulva can also be treated through Premarin.
  • An advanced form of prostate cancer and low estrogen after an operation to remove ovaries can also be treated through Premarin.
  • Another problem that Premarin can also treat is post-menopausal osteoporosis prevention.
  • Prolonged use of Premarin vaginal cream can also help the vaginal tissues by restoring their elasticity and thickness.

Premarin vaginal cream also helps to treat vaginal atrophy. Vaginal atrophy is a condition that occurs in women from the ages of 35 and above who experience vaginal dryness and symptoms related, and this is most often due to the loss of menopause-related estrogen. As the levels of estrogen diminish decrease in natural lubrication is experienced, and the skin lining vaginal walls start thinning.

A low dose of the vaginal cream may also be used to treat symptoms such as; urinary tract infections, urethral irritation, and urethral tissues being weak.

Side Effects of Premarin

It also comes with its own side-effects that one needs to be aware of before you start on the medication.

You need to inform your doctor before taking Premarin if you have the following conditions;

  • If you have a history of stroke, blood clot, or heart attack
  • If you have liver disease or unusual vaginal bleeding that has not been clearly checked by your doctor
  • If you have a history of breast cancer, cervix or vagina cancer, or even hormone-related cancer
  • If you have a blood disorder that is hereditary, a heart problem that leads to an increased blood clot risk
  • If you have or have ever had asthma
  • If you have lupus or migraines
  • If you have gallbladder disease or epilepsy

The side-effects of Premarin that are less common include; a headache, fever, nasal congestion, running nose, cough and chills, congestion of the ears and fever, sore throat, sneezing, feeling weak and tired, breathing difficulties, pain or body aches, and voice loss.

The most common side-effects of Premarin include; pain experienced during sexual intercourse, passing of gas, vaginal discharge that is white and thick with no mild odor or any odor at all, loss in strength, back pain, and excessive gas in the stomach.

It may also cause vomiting, nausea, changes in weight, breast tenderness, and bloating. If these conditions get worse you need to inform your doctor immediately.

If you see the tablet in your stool you also need to inform your doctor immediately.

Also, if you experience serious side-effects such as; vaginal bleeding, breast lumps, mood changes, among others, you should contact your doctor immediately.

Premarin Dosage

The dosage depends on your medical condition and the response to the treatment that you are getting.

The recommended dose in adults of the vaginal cream is from 0.5 to 2g per day. If the symptoms are quite a severe one may be recommended to insert the cream in the vagina using the provided applicator.

If one is taking the oral estrogen tablets it is always recommended to have the dose adjusted in case they start using the cream.

You also need to know that you should always follow your doctor’s prescription in order for the medication to be effective and perform according to its level best.

If you overdose or someone you know happens to overdose you need to contact emergency services immediately.

The medicine should be stored in a room temperature that is cool, away from sunlight and any moisture.

You should also note that the medication should not be shared with anyone else even if they have the same symptoms that you may be having.




Thomas Matthys a former world-class track & field athlete and the founder of Swol Headquarters. He graduated from the University of Fordham with a Master’s degree in Science. Matthys is a certified sports nutritionist and personal coach of several professional athletes.  Matthys has been involved in various clinical studies within Track & Field including one on the factors associated with muscle recovery and HIIT.

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