Andarine (S4) Review 2018- Benefits & Side Effects

What is Andarine (S4)?

S4 Andarine is a SARM manufactured by GTX, Inc. The compound was initially created by GTX to take care of osteoporosis, muscle wasting, bloated prostate and several other disorders. These days, it’s has gained immense popularity amongst the bodybuilders who prefer to use Andarine because of its steroid-like advantages.

When it comes to natural, steroid-like benefits, Andarine is usually considered the “weakest” amongst the four most in-demand SARMs on the market. As a matter of fact, the drug was initially produced for medical requirements, and therefore it is not associated with the same harmful side effects as SARMs such as LGD-4033, Ostarine, and the like.




We also refer to S4 Andarine as S4, S-4, or SARM S4 and thus whenever you observe individuals speaking about one of these things it is easy to understand that they are referring to none other than Andarine. Like all products in the SARM series, S4 or andarine is a potent SARM known for its strength gains and fat loss effects. Just like MK-2866 and LGD-4033, S4 was designed to counteract muscle wasting cancer and AIDs patients. Many steroids are considered cutting steroids such as Winstrol or Anavar, and anavar has great strength gains so that S4 can be considered as a bit of a weaker Anavar, but it is usually cheaper.

What is Andarine S4 used for?

Andarine has several alternative names including GTx-007, Acetamidoxolutamide, and Androxolutamide. The most commonly used alternate term is S-4. It is classified as an investigational new drug. Its IUPAC name is (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide, the CAS Number       is 401900-40-1, PubChem CID is 9824562, IUPHAR/BPS is 7849, DrugBank is DB07423, ChemSpider is 8000309, ChEMBL is CHEMBL125236 and ECHA InfoCard is 100.230.653. Andarine has a chemical formula of C19H18F3N3O6 and its molar mass is 441.357g/mol.

Andarine uses non-steroidal anti-androgen bicalutamide as its primary active compound. The pills or supplements are taken orally. Andarine is different from steroids that have historically been taken by athletes, sportspersons and bodybuilders. However, the product is taken by many fitness enthusiasts and weightlifters to increase muscle mass, strength, endurance, and fitness. The effect of andarine as compared to androgenic and anabolic steroids is less potent but this is also what makes the drug or supplement safer. The side effects are substantially reduced due to the targeted approach of andarine and how it interacts with only specific hormones, resulting in the growth of muscle tissues. Many androgenic and anabolic products actually have an adverse effect on healthy or lean mass. Anti-androgenic side effects are also common.

For bodybuilding purposes, it is usually combined in conjunction with other SARMs such as LGD-4033, Ostarine and Cardarine, to speed up size gains, strength gains and for fat loss.  It is also very popular for general, cosmetic effects for bodybuilding, as it dries you out slightly, making your muscles look “harder,” it greatly increases vascularity and even has slight joint healing effects.

Medical Purpose

Andarine is a selective androgen receptor modulator. It is referred to as S-4 by many but the actual classification is S-40503. Andarine was first developed by a pharmaceutical company in Japan called Kaken Pharmaceuticals. The brand developed andarine as a cure for osteoporosis. Andarine is not the only SARM being produced by pharmaceutical companies around the world. There are many types of SARMs and andarine is just one of those brands or groups. It is not the strongest selective androgen receptor modulator either. Many experts cite this as a good thing as the potential side effects, if any at all, is averted.

Andarine is an investigational SARM, which means it targets specific receptors and bind onto them. In this case, andarine targets androgen receptions in the muscles and bones. There is one common perception that SARMs like andarine would help one to gain several pounds in a very short span of time. This is an incorrect perception and clearly a misunderstanding of the medical purpose of this sarm. The purpose of andarine is not to help someone gain fifty pounds. The purpose is to prevent muscle wasting. One would not simply bulk up as would be the case with steroids. One would be able to prevent the loss of healthy muscles and can regain lean mass. Lean mass is not the same as fat ridden muscles. Andarine also helps in the retention of the lean mass, thereby benefitting overall health, provided the diet or nutrition remains balanced, one gets enough exercise and does not have any serious medical ailment that would further enhance the vulnerability of the person to muscle wasting or atrophy.


Andarine can also help a person to lose fat since the objective is to develop lean mass. Andarine is also less anabolic and more androgenic so the effect on fat is quite profound. Oxidation of fat caused by the androgenic hormones as andarine binds to the androgen reception in the adipose tissues, which is basically what fat is, leads to this loss of fat and in effect weight loss. This weight loss is healthy as compared to losing muscle mass. Andarine helps with strengthening muscles and preserving the mass in bones, even helping with regeneration and building stronger bones. The selective action of S4 limits its effects and hence also its side effects. Smaller doses of andarine may not provide quick results because of its low potency so you may opt for higher doses provided you do not have any serious health condition. Andarine does not have any effect on prostate weight when taken as a supplement. The pills are also mostly developed to treat muscle atrophy and osteoporosis.

Andarine vs. Steroids

Andarine and the likes of ostarine are still widely considered to be steroids, which is the primary reason why anti-doping agencies and sports federations around the world have banned their use. There is enough scientific evidence that proves andarine and ostarine among others to be different from the typical steroids that are banned by agencies and federations. Andarine or ostarine, which is also known as MK-2866, works like testosterone or Winstrol. These do not have the anabolic or androgenic results that one gets from actual steroids. Since the effects are similar, that of SARMs and actual steroids, the regulatory authorities are perhaps convinced that they are basically the same.

How does Andarine work?

The behavior of S4 Andarine can be compared with that of the androgen receptors’ orally activated partial agonist. In fact, according to one particular research, it was confirmed that Andarine was responsible for minimizing prostate weight just like finasteride; however, there were neither any decrease in muscular mass nor any anti-androgenic unwanted effect. This is very important since it implies that dihydrotestosterone (DHT) can be prevented by S4 for focusing on receptors without causing any damage to the muscle gains just like a 5a-reductase inhibitor (such as dutasteride or finasteride) might do.

Moreover, Andarine, much like all other SARMS, can affix to the androgen receptors and it does not trigger any androgenic action in the non-skeletal muscular tissues during the process. In reality, there is a general prediction that Andarine can attach around 50% as strong as straight testosterone without causing any androgenic side effect. Consequently, apart from its benefits for the females, it is also perfect for those men who have no intention of coping with androgenic side effects.

Stacking info

Although it is possible to use S4 Andarine on its own to improve toughness and also for cutting, it will provide the best results when utilized in a stack. This could be the other SARMS, or it could be utilized to boost the actions of the anabolic steroids while reducing the side effects at the same time.

How is it administered?

While using S4, one of most common forms of the drug happens to be liquid, and you may purchase it in different amounts as well as concentrations.

The normal recommendation is that it should be used for just five days out of every seven despite the fact that it can be utilized for an extended cycle. Some users would rather have one day off during the week and one more towards the end while others might decide on a five on, two off routine. This first mentioned routine helps to make sure that the SARM cycle is kept pretty constant without any fluctuations in the blood levels.

Half-life info

S4 Andarine is used as a short-acting medication since its half-life is only between 4 to 6 hours. Because of this, a lot of users prefer to split the dosage.

Application in sports activities

S4 Andarine is preferred within the bodybuilding community since it has been verified to provide desirable results in that particular department. As a matter of fact, there is an immense usage of Andarine in many sports like athletics, biking, and also baseball mainly because of its capability to maximize lean body mass and improve strength.


It has been verified by research that, regarding weight loss, the outcomes of S4 outshine that of the anabolic steroids.
S4 Andarine is a well-liked option just before competitions since it is inclined naturally to make a shredded and sculpted appearance. It can be included in an anabolic steroid to enhance a cutting cycle, or a SARMS stack may be produced, incorporating Andarine for a powerful weight loss cycle.


Andarine should ideally be taken in small doses. Some conditions demand high doses. A high dose of andarine may be suppressive for some hormones, their secretions and hence functions. The suppressive nature is not severe but it would be experienced by many. The best approach is to balance the dose if there are some suppressive side effects. Lower doses have no adverse effect. Since andarine is widely used during recovery, supplementation should be phased. There should be a well-planned cycle of increasing and decreasing the dosage. There are some minor short-term side effects such as feeling a little strange and difficulty while adjusting to the darkness. These would subside naturally in a few days.

The half-life of andarine or S-4 is four hours. This is substantially less than the half-life of ostarine which is around twenty-four hours and that should tell you the difference in their potencies. The daily dosage should be between 50mg and 75mg. The threshold of tolerance for andarine among adults is 100mg. Start on a small dose and then increase it slowly but steadily to maximize the benefits while minimizing the potential side effects. You may take a pill or go for andarine supplementation up to three times a day. Two times a day should be sufficient for most people. A course of weeks is typical in case of andarine. The supplement or drug has no impact on the liver so you need not worry about it like is the case with some other steroids and drugs that are hepatotoxic.

When you are using Andarine, it is essential to use the appropriate dosage. In case you are using S4 then it is compulsory to do it at 50 mg or 75 mg, and you must ensure that you get this done five days per week. You need to try to do this for a minimum of 12 weeks. Therefore it is now clear that you no longer need to take this thrice daily, but it will assist you to ensure that you bear in mind to take it regularly. Simply take 25 mg with three meals on a regular basis. If you wish to keep on receiving outcomes without having to run the appropriate cycle, then you will see that you reduce when it comes to the outcomes you receive. For instance, by taking S4 for more than 16 weeks, you are not going to obtain any additional muscle tissue while you might even encounter more unwanted effects at the same time. This will make you invest your time as well as money, and it is an essential thing that must be taken into consideration. In case you prefer to start cutting the ideal thing that you can do, will be using 50 mg for 6 to 9 weeks. Make it a point to take it every single day; otherwise, it will be very hard to get the desired results.


S4 is not the best option for users that are trying to build muscle despite the fact that it is a very well-liked form of SARMS. Andarine can easily pack on muscle tissue gains with adequate workout and additional calories; however, there will not be any rapid growth which is usually noticed within a bulking cycle while it’s used solo.
Nevertheless, S4 could be very beneficial when it is included in a bulking stack since it is going to improve the actions of various other bulking drugs while also lowering swelling and enhancing lean mass.


Andarine is great at ramping up power, providing gains that are not only simple to maintain but also extremely clean and fast. When our primary objective happens to be toughness, it is recommended to use a dose of approximately 50 mg, possibly increasing to 75 mg. S4 is well known for its ability to ramp up power, with outcomes beginning to become apparent in only over a week.

S4 can also be ideal for recomping while stacked with an additional SARM that has a better anabolic impact, for example, Ostarine. For this one should use this drug at 50-75 mg for a period spanning over 4 to 8 weeks.

For optimum recomping, it will be advisable to stack Andarine along with Cardarine and Ostarine for a double stack which is going to provide the best outcomes without any unwanted side effects. Additionally, one should make it a point to consume a diet that has at least 30% of the calories originating from lean protein.

Positive effects

There are lots of benefits that can be acquired by making use of Andarine.

It comes with an outstanding ability to get rid of excess body fat while improving skeletal muscle power along with lean muscle mass. This weight loss will not result in catabolism in contrast to a few other forms of supplement. Andarine S4 furthermore offers a hard and lean appearance by drying out the muscle mass, which makes it a hot favorite as a pre-competition drug.

According to several studies, it is possible to use S4 for minimizing gynecomastia due to its androgenic effect.

Andarine, apart from the SARMS muscle building usage, helps in the remedying of muscle losing ailment along with harmless prostate hypertrophy.

Andarine Side effects 

Obviously, you will need to comprehend that Andarine is not the most effective supplement on the market since there isn’t one generally speaking. The positive thing is that, as compared with the other available supplements, Andarine will not provide you with half the intensity of side effects; however, it is not free from several drawbacks. The 1st drawback is that, following a milligram percent, it will no longer be much reliable. You may take 75 mg of this each day; however, things could get unpleasant for you if you happen to exceed this limit. You should remain under this range simply because your system won’t be in a position to endure it in case you do go any higher and therefore ensure to consider this before you increase it. Now the question is that what exactly are the negative effects to be aware of? Confronting with visual problems is probably the most well-known one that you might expect. You might realize the fact that you are finding it tougher to see at nighttime and you might even find that you have got a yellowish shade in the eyes and. This being exclusive to S4 Andarine, in some cases, you might find that they’re overblown too. It would be much better to quit using S4 in case you come to realize that you have been afflicted with all these unwanted effects and while doing so ensure that you remain on a routine of five days on, two days off. All these effects aren’t everlasting whatsoever, and once the SARM is out of your body, you will feel confident realizing that they are going to disappear entirely.

In this way, it is now evident that S4 could cause depressive disorders as well. In case you realize that you are vulnerable to depressive disorders or you do have an ailment then you might find that you are going through more outbursts of negativity; therefore in case you belong to this particular group make certain that you use this product very meticulously or do anything that you can for taking it at the smallest dosage feasible.

Side effects from S4 are the harshest out of all the SARMs, however they are very manageable, the worst being a slight yellow tinge in your eyesight and worsened night vision, which can be a hassle when driving at night, although many users report driving to be fine, luckily, these side effects are NOT permanent and are usually gone completely within a few days.  The other side effects include decent strength gains and slight HTPA suppression.


How to use Andarine

Andarine is usually used in conjunction with other arms like above, but it can be dosed anywhere from the 50-150mg day. Dosing for bulking or recaps should be 50mg or higher, but cutting should stay at 50mg. As Andarine (s4) has a short halflife, splitting up the dose to 2 or 3x a day is optimal, to keep levels in the body high.
It can also be dosed 1 hour before a workout, only on workout days and this is called Pulsing, resulting in some slight fat loss, but decent strength gains.
S4 is usually dosed on a five day on, two days off schedule (Monday to Friday on, Weekends off) to reduce the side effects affecting eyesight.


Why should you use Andarine over Steroids?

  • The LDL/ HDL proportion isn’t afflicted which it makes a low cardio threat.
  • Testosterone is not reduced in any capacity throughout the post cycle recovery.
  • Extremely minimum development of secondary sexual body organs like the prostate.
  • SARMs do not need the utilization of liver enzymes for activating their anabolic effects. This eliminates any danger of hepatitis or hepatotoxicity.
  • 0% possibility of male breast lactation, aromatization, or perhaps rise of any other female feature throughout the post cycle recuperation.
  • Extremely exclusive in the selection plus growth meaning it will never cause heart enhancement or harm to the nearby organs.Although SARMs such as S-4 are not as powerful as similar steroids like Winstrol, they don’t need the intensive post cycle treatment and can be cycled continuously all year round.
  • SARMs are extremely female friendly and don’t cause excessive masculine attributes such as enlarged sexual features.
  • S4 Andarine offers bigger enhancements in the muscle tissue as compared to DHT.

Is Andarine legitimate?

The Anti-Doping Organization, by their 2008 decision, has prohibited the use of Andarine, just like all other SARMs. Therefore, you must not use Andarine should you be taking part in any fitness competition under the legislation of that company.

If, however, you are using Andarine for personal usage, using this supplement will not be that offensive in the end. At present, nobody is certain whether SARMs are lawful or illegal. The FDA’s 2014 choice to sanction the Designer Anabolic Steroid Control Act (DASCA) caused it to be efficiently unlawful to market anabolic steroid drugs, creating SARMs and the next-best lawful option.

Nevertheless, even the most optimist muscle building supplement companies don’t assume that SARMs such as Andarine will remain legitimate for a considerable period.

A portion of the issue depends on the effective insurance plans of the supplement. As stated before, the supplement was at first developed so that you can treat osteoporosis, minimize larger prostate issues, and also minimize the symptoms of muscle wasting disease. Consequently, Andarine is considered to be a positively researched medical drug by lots of people and this should be sufficient to put it underneath the legislation of the FDA.

However, the same scrutiny as Ostarine and some other SARMs has not been experienced by Andarine, and it is not the topic of any lawsuits as well.


Being an extremely powerful muscle hardener S4 can likewise be a strong lean mass builder at high dosages. It provides outstanding results in cutting stages or body recomposition stages. S4 easily outclasses other SARMs when it comes to including grainy, dry detail to a complicated physical structure and thus it is undoubtedly the most effective pre-contest SARM.


Scott Williams has a Master’s Degree in Nutrition and is a Certified Personal Trainer. Apart from being an integral part of our research team, Scott Williams spends almost every single minute he can get in the gym. He has vast experience in matters supplements, diets, and workouts.

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